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What is Losartan potassium?


Losartan potassium is an orally active, nonpeptide angiotensin II (AII) receptor antagonist. It is the aboriginal of a new chic of drugs to be alien for analytic use in hypertension. This atypical abettor binds competitively and selectively to the AII subtype 1 (AT(1)) receptor, thereby blocking AII-induced physiological effects. An alive metabolite, E3174, contributes essentially to its antihypertensive effect, which persists throughout 24 hours afterwards once-daily administration. In patients with balmy to abstinent hypertension, losartan potassium 50 to 100mg already circadian as monotherapy lowers claret burden to a agnate amount to enalapril, atenolol and felodipine continued absolution (ER).

Losartan potassium accumulated with hydrochlorothiazide reduces claret burden added than either biologic accustomed separately. About one-third of patients with astringent hypertension accept responded to the aggregate product. Losartan potassium appears to be able in aged patients. Losartan potassium is actual able-bodied tolerated. In analytic trials, blackout was the alone drug-related accident appear added frequently with losartan potassium monotherapy than with placebo. First-dose hypotension is uncommon. 

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2017-8-27 category: APIs/

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