Introduction of Lutrol E 300/400/600
Types are liquid polyethylene glycols manufactured by alkali-catalysed polymerisation of ethylene oxide with subsequent neutralisation of the catalyst. Lutrol E grades are readily soluble in water, ethanol, acetone, glycols and chloroform. The number in the name of the product is indicative of the average molecular weight. The higher the molecular weight of the product; the less hygroscopic it is and lower it’s solubility in water.
Lutrol E 300/400/600 and Lutrol E 400 are colourless, almost odourless and tasteless liquids at room temperature; while Lutrol E 300/400/600 can be either liquid or pasty at room temperature.
Lutrol E 300/400/600 are potential drug carriers for humanizing the therapeutic index of anti-cancer agents. This paper reports on the modification of the anticancer drugs, methotrexate and melphalan, covalently linked to PEGs for drug delivery… Evaluation of the in vitro cytotoxicity of the drug polymer conjugates on the U87MG human glioma cell line revealed that the conjugates showed enhanced dose-dependent cytotoxicity.