Protective effect of Flos puerariae extract
The aftereffect of Flos Puerariae Extract (FPE) on booze metabolism, hepatic injury, and anamnesis crime was adjourned afterward astute booze (EtOH) beatitude in mice.
METHODS:The archetypal of astute EtOH beatitude was accustomed by intragastric administering with 8 g/kg EtOH in mice. FPE was orally administrated (gavage) already a day for 7 afterwards days. Mice were about disconnected into 4 groups: ascendancy group, archetypal group, and FPE groups (100, 200 mg/kg). Booze altruism and beatitude time, claret booze concentration, the activities of booze dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in liver, aspartate amino transferase (AST) and alanine amino transferase (ALT) in serum, superoxide dismutase (SOD), glutathione peroxidase (GSH-px), catalase and the accumulation of malondialdehyde (MDA) in both alarmist and brain, as able-bodied as anamnesis adeptness were bent afterwards astute booze exposure.
RESULTS:Compared with archetypal group, pretreatment with FPE decidedly abiding booze altruism time and beneath beatitude time, which is accompanied by decreased claret booze absorption and animated activities of ADH and ALDH in liver. Moreover, the basis of hepatic injury, ALT, and AST activities in serum was clearly decreased by pretreatment withFPE. Additionally, decreased MDA level, added GSH-px and catalase activities in liver, as able-bodied as added SOD and catalase activities in academician were begin in FPE pretreated mice afterwards astute acknowledgment to EtOH. Furthermore, FPE pretreated mice showed clearly adequate anamnesis disruption afterward astute EtOH intoxication.
CONCLUSIONS:This abstraction suggests that FPE pretreatment could enhance booze metabolism, anticipate hepatic injury, and abate anamnesis crime afterwards astute booze beatitude and that this aftereffect is acceptable accompanying to its accentuation on the booze metabolizing and antioxidant enzymes.