Effects of gomisin

  Schiandra chinensis is a acclaimed Chinese acceptable anesthetic for the analysis of hepatic disease. In this study, we advised whether the nine above compounds of Schiandra chinensis could be activated to abolish lipopolysaccharide (LPS)-induced anarchic responses in murine macrophages (Raw 264.7 cells). Among the nine lignans, three, gomisin, and schisandrin C, were begin to abate nitric oxide (NO) assembly from LPS-stimulated Raw 264.7 cells. These three lignans showed low cytotoxic furnishings in Raw 264.7 cells. Pre-treatment of Raw 264.7 beef with gomisin, or schisandrin C bargain the announcement of mRNA and the beard of pro-inflammatory cytokines. These inhibitory furnishings were begin to be acquired by blockage of p38 mitogen-activated protein kinase (MAPK), extracellular signal–regulated kinases 1 and 2 (ERK 1/2), and c-Jun N-terminal kinase (JNK) phosphorylation.
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